A Clinically Proven Treatment For Allergies And Small Airway Disease In Performance Horses

Horses improved clinically when this drug was given by nebulization in the following clinical study.

Of 10 Standardbreds and 2 Thoroughbreds in racing condition and with signs of allergies and small airway disease, 6 horses placed on "sodium cromoglycate" nebulization showed clinical improvement. Prior to treatment, signs included coughing, expiratory distress, dyspnea, and submaximal performance of fewer than 2 weeks duration. Bronchoalveolar lavages revealed increased metachromatic cell differential counts. Horses were nebulized with either a sterile isotonic placebo (10ml) or 200mg (10ml) sodium cromoglycate for 5 days. Prior to and within 2 hours of the final treatment, all horses were given a clinical respiratory exam, and a bronchoscopic bronchoalveolar lavage was performed. Histamine quantitation was carried out on metachromatic cells, lavage supernatant, and cell lysate by radioimmunoassay. All horses treated with sodium cromoglycate (Cromolyn Sodium) showed a significant improvement in their clinical respiratory exam and a reduction in metachromatic cell histamine levels. Metachromatic cells, which exhibit metachromasia, may be important in the pathophysiology of small airway disease due to the release of inflammatory mediators and chemoattractants.

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